PublicationsPublications
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Key Publications: Li, H., and Guo, M. (2009) Protein Degradation in Parkinson Disease Revisited: It's Complex. J. Clinical Invest: 119(3):442-5. [pdf] Yun, J., Cao, J.H., Dodson, M.W., Clark, I.E., Kapahi, P., Chowdhury, R.B. and Guo, M. (2008) Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the pink1/parkin pathway in vivo. Journal of Neuroscience 28: 14500-14510. [pdf] Deng, H., Dodson, M.W., Huang, H. and Guo, M. (2008) The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. PNAS, 105: 14503-14508. [pdf] Gross, G., Feldman, R.M.*, Ganguly, A.*, Wang, J.H., Yu, H. and Guo, M. (2008) Role of X11 and ubiquilin as in vivo regulators of the Amyloid Precursor Protein in Drosophila. PLoS ONE, 3(6):e2495. (*equal contribution). [pdf] Ganguly, A.*, Feldman, R.M.*, and Guo, M. (2008) ubiquilin antagonizes presenilin and promotes neurodegeneration. Hum. Mol. Genet. 17:293-302 (*equal contribution) [pdf] (Cover story) Dodson, M.W. and Guo, M. (2007) Pink1, Parkin, DJ-1 and Mitochondrial Dysfunction in Parkinson's Disease. Curr. Opin. Neurobiol. 17: 331-337. [pdf] Chen, C., Huang, H., Ward, C., Su, J., Schaeffer, L., M. Guo and Hay, B.A. (2007) A Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila. Science. 316: 597-600 [pdf] Clark I.E.*, Dodson M.W.*, Jiang C.*, Cao J.H., Huh J.R., Seol J., Yoo S., Hay, B.A. and Guo, M. (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature, 441: 1162-1166. [pdf] (*equal contribution) [This paper is featured by Nature, Cell, Neuron and Lancet Neurology.] Hay, B.A. and Guo, M. (2006) Caspase-Dependent Cell Death in Drosophila. Annu. Rev. Cell Dev. Biol., 22: 623-650. [pdf] Hay B.A., Huh J.R. And Guo M. (2004) The genetics of cell death: approaches, insights and opportunities in Drosophila. Nat. Rev. Genet. 5: 911-922. [pdf] Guo, M.*, Hong, E., Fernandes, J., Zipursky, S.L., and Hay, B. (2003) A reporter for amyloid precursor protein gamma-secretase activity in Drosophila. Hum. Mol. Genet. 12:2669-2678. (*Corresponding author) [pdf] [This paper is ranked “exceptional” with a ranking factor of 9.0 by Faculty of 1000 (http://www.facultyof1000.com/article/12944419). It is ranked as “the top ten papers” in November 2003.] Other Publications: Huh JR, Foe I, Muro I, Chen CH, Seol JH, Yoo SJ, Guo M, Park JM, Hay BA. (2007) The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers. J Biol Chem. 282: 2056-68. [pdf] Chen CH, Guo M, Hay BA. (2006) Identifying microRNA regulators of cell death in Drosophila. Methods Mol Biol. 342: 229-40. Muro I, Berry DL, Huh JR, Chen CH, Huang H, Yoo SJ, Guo M, Baehrecke EH, Hay BA. (2006) The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process. Development. 133: 305-15.[pdf] Huh J.R., Guo M. and Hay B.A. (2004) Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role. Current Biology 14:1262-1266. [pdf] Hay B.A. and Guo M. (2003) Coupling cell growth, proliferation and death: Hippo weighs in. Dev. Cell 5:361-363. [pdf] Huh, J.R. , Vernooy, S.Y., Yu, H. , Yan, N. , Shi, Y. , Guo, M., Hay, B.A.
(2004) Multiple Apoptotic Caspase Cascades Are Required in Nonapoptotic Roles
for Drosophila Spermatid Individualization. PLOS Biology, 1: 43-44. [pdf] Xu, P., Vernooy, S.Y., Guo, M., and Hay, B.A. (2003) The Drosophila microRNA mir-14 suppresses cell death and is required for normal fat metabolism. Current Biology, 13: 790-795. [pdf] [This paper is featured in Cell (2003) 113:673-676. The Scientist (2003) June 16. Current Biology (2003) 13: R473-R475.] Guo, M. and Hay, B. (1999) Cell proliferation and apoptosis. Current Opinion in Cell Biology 11: 745-752. [pdf] Publications before Dr. Guo became a faculty Guo, M., Jan, L.Y., and Jan, Y.N. (1996) Control of daughter cell fates during asymmetric division, interaction of Numb and Notch, Neuron 17: 27-41. [pdf] [This paper is featured in the following review. Campos-Ortega JA. "Numb diverts Notch pathway off the tramtrack." Neuron 1996, 17:1-4, and Trends in Genetics, 1996, 10: 399.] Guo, M., Bier, E., Jan, L.Y., and Jan, Y.N. (1995) tramtrack acts as a
downstream gene of numb in specifying distinct daughters during multiple
asymmetric divisions in the Drosophila PNS. Neuron 14: 913-925. [pdf] [This paper was featured in the following review. Badenhorst,
P., Gold, M. S., White, D.M., |